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Risks of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may well result in a rise in tramadol plasma degrees and also a lower in the amounts of the Energetic metabolite, M1.Really serious and almost nev